Stress transforms lateral habenula reward responses into punishment signals

Steven J. Shabel, Chenyu Wang, Bradley Monk, Sage Aronson, Roberto Malinow

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression [C. D. Proulx, O. Hikosaka, R. Malinow, Nat. Neurosci. 17, 1146–1152 (2014)], decreases during reward and increases during punishment or reward omission [M. Matsumoto, O. Hikosaka, Nature 447, 1111–1115 (2007)]. While stress is a major risk factor for depression and strongly impacts the LHb, its effect on LHb reward signals is unknown. Here we image LHb neuronal activity in behaving mice and find that acute stress transforms LHb reward responses into punishment-like neural signals; punishment-like responses to reward omission also increase. These neural changes matched the onset of anhedonic behavior and were specific to LHb neurons that distinguished reward and its omission. Thus, stress distorts LHb responsivity to positive and negative feedback, which could bias individuals toward negative expectations, a key aspect of the proposed pathogenesis of depression [A. T. Beck, Depression: Clinical, Experimental, and Theoretical Aspects, sixth Ed (1967)].

Original languageEnglish (US)
Pages (from-to)12488-12493
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number25
DOIs
StatePublished - Jun 18 2019

Keywords

  • Anhedonia
  • Habenula
  • Prediction error
  • Reward
  • Stress

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Stress transforms lateral habenula reward responses into punishment signals'. Together they form a unique fingerprint.

Cite this