Stress transforms lateral habenula reward responses into punishment signals

Steven Shabel, Chenyu Wang, Bradley Monk, Sage Aronson, Roberto Malinow

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression [C. D. Proulx, O. Hikosaka, R. Malinow, Nat. Neurosci. 17, 1146–1152 (2014)], decreases during reward and increases during punishment or reward omission [M. Matsumoto, O. Hikosaka, Nature 447, 1111–1115 (2007)]. While stress is a major risk factor for depression and strongly impacts the LHb, its effect on LHb reward signals is unknown. Here we image LHb neuronal activity in behaving mice and find that acute stress transforms LHb reward responses into punishment-like neural signals; punishment-like responses to reward omission also increase. These neural changes matched the onset of anhedonic behavior and were specific to LHb neurons that distinguished reward and its omission. Thus, stress distorts LHb responsivity to positive and negative feedback, which could bias individuals toward negative expectations, a key aspect of the proposed pathogenesis of depression [A. T. Beck, Depression: Clinical, Experimental, and Theoretical Aspects, sixth Ed (1967)].

Original languageEnglish (US)
Pages (from-to)12488-12493
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number25
DOIs
StatePublished - Jun 18 2019

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Habenula
Punishment
Reward
Depression
Neurons
Brain

Keywords

  • Anhedonia
  • Habenula
  • Prediction error
  • Reward
  • Stress

ASJC Scopus subject areas

  • General

Cite this

Stress transforms lateral habenula reward responses into punishment signals. / Shabel, Steven; Wang, Chenyu; Monk, Bradley; Aronson, Sage; Malinow, Roberto.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 25, 18.06.2019, p. 12488-12493.

Research output: Contribution to journalArticle

Shabel, Steven ; Wang, Chenyu ; Monk, Bradley ; Aronson, Sage ; Malinow, Roberto. / Stress transforms lateral habenula reward responses into punishment signals. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 25. pp. 12488-12493.
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