Abstract
Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [3H]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogenous. The ventral caudate-putamen displayed the greatest decrease in both [3H]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.
Original language | English (US) |
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Pages (from-to) | 321-326 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 598 |
Issue number | 1-2 |
DOIs | |
State | Published - Dec 11 1992 |
Keywords
- Autoradiography
- Dopamine
- Heterogeneity
- Mazindol
- Methamphetamine
- Neurotoxicity
- Rat
- Striatum
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology