Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine

Amelia J. Eisch, Mary Gaffney, Fredric B. Weihmuller, Steven J. O'Dell, John F. Marshall

Research output: Contribution to journalArticle

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Abstract

Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [3H]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogenous. The ventral caudate-putamen displayed the greatest decrease in both [3H]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalBrain Research
Volume598
Issue number1-2
DOIs
StatePublished - Dec 11 1992

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Keywords

  • Autoradiography
  • Dopamine
  • Heterogeneity
  • Mazindol
  • Methamphetamine
  • Neurotoxicity
  • Rat
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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