Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer

Moriah M. Hagopian, Rolf A. Brekken

Research output: Contribution to journalComment/debatepeer-review

3 Scopus citations

Abstract

The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.

Original languageEnglish (US)
Article numbere975606
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Keywords

  • TGF-β
  • epithelial to mesenchymal transition
  • metastasis
  • pancreatic cancer
  • tumor–stroma interactions

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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