Stromal TGFβR2 signaling

a gateway to progression for pancreatic cancer

Moriah M. Hagopian, Rolf A. Brekken

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.

Original languageEnglish (US)
Article numbere975606
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Fingerprint

Pancreatic Neoplasms
Adenocarcinoma
Transforming Growth Factors
Heterografts
Neoplasm Metastasis
Antibodies
Therapeutics

Keywords

  • epithelial to mesenchymal transition
  • metastasis
  • pancreatic cancer
  • TGF-β
  • tumor–stroma interactions

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

Cite this

Stromal TGFβR2 signaling : a gateway to progression for pancreatic cancer. / Hagopian, Moriah M.; Brekken, Rolf A.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e975606, 03.07.2015.

Research output: Contribution to journalComment/debate

@article{122965600faf46e0b2db6e2e43a27db5,
title = "Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer",
abstract = "The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.",
keywords = "epithelial to mesenchymal transition, metastasis, pancreatic cancer, TGF-β, tumor–stroma interactions",
author = "Hagopian, {Moriah M.} and Brekken, {Rolf A.}",
year = "2015",
month = "7",
day = "3",
doi = "10.4161/23723556.2014.975606",
language = "English (US)",
volume = "2",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Stromal TGFβR2 signaling

T2 - a gateway to progression for pancreatic cancer

AU - Hagopian, Moriah M.

AU - Brekken, Rolf A.

PY - 2015/7/3

Y1 - 2015/7/3

N2 - The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.

AB - The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.

KW - epithelial to mesenchymal transition

KW - metastasis

KW - pancreatic cancer

KW - TGF-β

KW - tumor–stroma interactions

UR - http://www.scopus.com/inward/record.url?scp=85018472681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018472681&partnerID=8YFLogxK

U2 - 10.4161/23723556.2014.975606

DO - 10.4161/23723556.2014.975606

M3 - Comment/debate

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 3

M1 - e975606

ER -