Structural and genetic analysis of four chicken 7S immunoglobulin allotypes

Edward K. Wakeland, Albert A. Benedict

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Four 7S immunoglobulin allotypic specificities in three inbred chicken lines were demonstrated in two immunoglobulin regions, probably associated with the heavy chains. Two specificities were associated with papain-produced Fab fragments, most likely the Fd fragment since they were not demonstrated on the 17S immunoglobulin. The other allotypes were detected only on intact 7S immunoglobulin and were undetectable on the Fab and Fc fragments; therefore, they probably were associated with a region of the heavy chain sensitive to papain digestion. Among F2 hybrids, these specificities segregated in a manner statistically indistinguishable from that expected of three codominant alleles at an autosomal locus. This locus was not closely associated with any of five chicken blood group loci.

Original languageEnglish (US)
Pages (from-to)531-541
Number of pages11
JournalImmunogenetics
Volume2
Issue number1
DOIs
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Immunology
  • Genetics

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