Structural basis for assembly and disassembly of the CRM1 nuclear export complex

Xiuhua Dong, Anindita Biswas, Yuh Min Chook

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

CRM1 (or exportin 1, Xpo1) transports proteins out of the cell nucleus through the nuclear pore complex. In the cytoplasm, GTP hydrolysis and consequent dissociation of Ran from CRM1 releases low-affinity substrates, while additional factors facilitate release of high-affinity substrates. Here we provide a model for human CRM1 export complex assembly and disassembly through structural and biochemical analyses of CRM1 bound to the substrate snurportin 1 (SNUPN, also called snuportin 1).

Original languageEnglish (US)
Pages (from-to)558-560
Number of pages3
JournalNature Structural and Molecular Biology
Volume16
Issue number5
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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