Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II

Kenneth D. Westover, David A. Bushnell, Roger D. Kornberg

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

The structure of an RNA potymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.

Original languageEnglish (US)
Pages (from-to)1014-1016
Number of pages3
JournalScience
Volume303
Issue number5660
DOIs
StatePublished - Feb 13 2004

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