Structural comparisons of serologically indistinguishable H-2K-encoded antigens from inbred and wild mice

B. Arden, E. K. Wakeland, J. Klein

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Abstract

H-2K glycoproteins from 2 wild-derived strains, B10.KPB128 and B10.GAA37, and from standard congenic lines B10.S(9R) and B10.A were compared by ionexchange chromatography of tryptic peptides. The H-2K products of B10.S(9R) and B10.A were found to differ in about 33% of their peptides. The H-2K molecule of B10.S(9R) was indistinguishable from the H-2K molecules of B10.GAA37 and B10.KPB128. These results indicate that the H-2K-encoded products of the B10.S(9R), B10.KPB128, and B10.GAA37 lines are structurally very similar or, perhaps, identical, suggesting that some alleles of the H-2K locus may be maintained in a stable form in allopatric populations of wild mice.

Original languageEnglish (US)
Pages (from-to)2424-2428
Number of pages5
JournalJournal of Immunology
Volume125
Issue number6
StatePublished - 1980

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Antigens
Peptides
Chromatography
Glycoproteins
Alleles
Population

ASJC Scopus subject areas

  • Immunology

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Structural comparisons of serologically indistinguishable H-2K-encoded antigens from inbred and wild mice. / Arden, B.; Wakeland, E. K.; Klein, J.

In: Journal of Immunology, Vol. 125, No. 6, 1980, p. 2424-2428.

Research output: Contribution to journalArticle

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