Structural differences between proteins with similar sequences

Qian Cong, Bong Hyun Kim, Lisa N. Kinch, Nick V. Grishin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Similarity between protein sequences is usually predictive of similarity in structures. However, in some rare cases protein domains with significant sequence similarity adopt different structures. Here, we carry out a survey of protein domain pairs with high sequence similarity (measured by HHsearch probability) and low structural similarity (measured by Dali Z-score), aiming to identify the reasons for this discordance. Besides methodological problems with either sequences or structures of domains, we find and describe novel examples of homologs with structural changes.

Original languageEnglish (US)
Title of host publication10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010
Pages250-256
Number of pages7
DOIs
StatePublished - Sep 6 2010
Event10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010 - Philadelphia, PA, United States
Duration: May 31 2010Jun 3 2010

Publication series

Name10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010

Other

Other10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010
CountryUnited States
CityPhiladelphia, PA
Period5/31/106/3/10

Keywords

  • Domain
  • Evolution
  • Homolog
  • SCOP
  • Superfamily

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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  • Cite this

    Cong, Q., Kim, B. H., Kinch, L. N., & Grishin, N. V. (2010). Structural differences between proteins with similar sequences. In 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010 (pp. 250-256). [5521682] (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010). https://doi.org/10.1109/BIBE.2010.48