Structural mechanisms in NLR inflammasome assembly and signaling

Zehan Hu, Jijie Chai

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Inflammasomes are multimeric protein complexes that mediate the activation of inflammatory caspases. One central component of inflammasomes is nucleotide-binding domain (NBD)-and leucine-rich repeat (LRR)-containing proteins (NLRs) that can function as pattern recognition receptors (PRRs). In resting cells, NLR proteins exist in an auto-inhibited, monomeric, and ADP-bound state. Perception of microbial or damage-associated signals results in NLR oligomerization, thus recruiting inflammatory caspases directly or through the adaptor molecule apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC). The assembled NLR inflammasomes serve as dedicated machinery to facilitate the activation of the inflammatory caspases. Here, we review current understanding of the structures of NLR inflammasomes with an emphasis on the molecular mechanisms of their assembly and activation. We also discuss implications of the self-propagation model derived from the NAIP-NLRC4 inflammasomes for the activation of other NLR inflammasomes and a potential role of the C-terminal LRR domain in the activation of an NLR protein.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages23-42
Number of pages20
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume397
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Fingerprint

Inflammasomes
Caspases
Pattern Recognition Receptors
Leucine
Adenosine Diphosphate
Proteins
Apoptosis
NLR Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Hu, Z., & Chai, J. (2016). Structural mechanisms in NLR inflammasome assembly and signaling. In Current Topics in Microbiology and Immunology (pp. 23-42). (Current Topics in Microbiology and Immunology; Vol. 397). Springer Verlag. https://doi.org/10.1007/978-3-319-41171-2_2

Structural mechanisms in NLR inflammasome assembly and signaling. / Hu, Zehan; Chai, Jijie.

Current Topics in Microbiology and Immunology. Springer Verlag, 2016. p. 23-42 (Current Topics in Microbiology and Immunology; Vol. 397).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hu, Z & Chai, J 2016, Structural mechanisms in NLR inflammasome assembly and signaling. in Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol. 397, Springer Verlag, pp. 23-42. https://doi.org/10.1007/978-3-319-41171-2_2
Hu Z, Chai J. Structural mechanisms in NLR inflammasome assembly and signaling. In Current Topics in Microbiology and Immunology. Springer Verlag. 2016. p. 23-42. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-319-41171-2_2
Hu, Zehan ; Chai, Jijie. / Structural mechanisms in NLR inflammasome assembly and signaling. Current Topics in Microbiology and Immunology. Springer Verlag, 2016. pp. 23-42 (Current Topics in Microbiology and Immunology).
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