TY - JOUR
T1 - Structural, mechanistic and functional insights into topoisomerase II
AU - Qin, Shang Yao
AU - Yuan, Yi Min
AU - Hu, Xin
AU - Sun, Xiu
AU - Su, Zhi Da
PY - 2016/2/25
Y1 - 2016/2/25
N2 - Topoisomerases are nuclear enzymes that regulate the overwinding or underwinding of DNA helix during replication, transcription, recombination, repair, and chromatin remodeling. These enzymes perform topological transformations by providing a transient DNA break, through which the unique problems of DNA entanglement that occur owing to unwinding and rewinding of the DNA helix can be resolved. In mammals, topoisomerases are classified into two types, type I topoisomerase (Top1) and type II topoisomerase (Top2), depending on the number of strands cut in one round of action. Top1 induces single-strand breaks in DNA, and Top2 induces double-strand breaks. In cells from vertebrate species, there are two forms of Top2, designated alpha and beta. Top2α is involved in the cellular proliferation and pluripotency, while Top2β plays key roles in neurodevelopment. In this review, we cover recent advances in structural, mechanistic and functional insights into Top2.
AB - Topoisomerases are nuclear enzymes that regulate the overwinding or underwinding of DNA helix during replication, transcription, recombination, repair, and chromatin remodeling. These enzymes perform topological transformations by providing a transient DNA break, through which the unique problems of DNA entanglement that occur owing to unwinding and rewinding of the DNA helix can be resolved. In mammals, topoisomerases are classified into two types, type I topoisomerase (Top1) and type II topoisomerase (Top2), depending on the number of strands cut in one round of action. Top1 induces single-strand breaks in DNA, and Top2 induces double-strand breaks. In cells from vertebrate species, there are two forms of Top2, designated alpha and beta. Top2α is involved in the cellular proliferation and pluripotency, while Top2β plays key roles in neurodevelopment. In this review, we cover recent advances in structural, mechanistic and functional insights into Top2.
UR - http://www.scopus.com/inward/record.url?scp=85021389112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021389112&partnerID=8YFLogxK
M3 - Article
C2 - 26915327
AN - SCOPUS:85021389112
SN - 0371-0874
VL - 68
SP - 98
EP - 106
JO - Sheng li xue bao : [Acta physiologica Sinica]
JF - Sheng li xue bao : [Acta physiologica Sinica]
IS - 1
ER -