Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion

R. G. Cook, E. S. Vitetta, J. W. Uhr, J. D. Capra

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Abstract

The E/C α- and β-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C α-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides: the E/C β-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C β-polypeptide is within the I-A subregion.

Original languageEnglish (US)
Pages (from-to)981-986
Number of pages6
JournalJournal of Experimental Medicine
Volume149
Issue number4
StatePublished - 1979

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Isoantigens
Genes
Peptide Mapping
polypeptide C

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion",
abstract = "The E/C α- and β-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C α-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides: the E/C β-chains from B10.A and 3R (or 5R) were approximately 40{\%} different. This suggests that the structural gene for the E/C β-polypeptide is within the I-A subregion.",
author = "Cook, {R. G.} and Vitetta, {E. S.} and Uhr, {J. W.} and Capra, {J. D.}",
year = "1979",
language = "English (US)",
volume = "149",
pages = "981--986",
journal = "Journal of Experimental Medicine",
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AU - Cook, R. G.

AU - Vitetta, E. S.

AU - Uhr, J. W.

AU - Capra, J. D.

PY - 1979

Y1 - 1979

N2 - The E/C α- and β-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C α-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides: the E/C β-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C β-polypeptide is within the I-A subregion.

AB - The E/C α- and β-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C α-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides: the E/C β-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C β-polypeptide is within the I-A subregion.

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VL - 149

SP - 981

EP - 986

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