Structural studies on the murine Ia alloantigens. VI. Evidence that both subunits of the I-A alloantigen are encoded by the I-A subregion

R. G. Cook, J. D. Capra, J. L. Bednarczyk, J. W. Uhr, E. S. Vitetta

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Abstract

The α and β subunits of the murine I-A alloantigens from several H-2 haplotypes were examined by comparative tryptic peptide mapping by using double label ( 3H and 14C) techniques. Significant structural variation between alleles was detected in both subunits. Tryptic digests of the α polypeptides from s, b, and d showed only 65% co-elution with k; β-chains from s, b, d, and r were about 50% similar to the k β subunit. Peptide analysis of the A(k) subunits from intra-H-2 recombinant strains indicated that both the α and β polypeptides are encoded within the I-A subregion.

Original languageEnglish (US)
Pages (from-to)2799-2804
Number of pages6
JournalJournal of Immunology
Volume123
Issue number6
StatePublished - Dec 1 1979

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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