TY - JOUR
T1 - Structure and biological properties of three calcitonin receptor-stimulating peptides, novel members of the calcitonin gene-related peptide family
AU - Katafuchi, Takeshi
AU - Minamino, Naoto
N1 - Funding Information:
This work was supported in part by Research Grants from the Ministry of Education, Culture, Sports, Science, and Technology (Special Coordination Funds for the Promotion of Science and Technology), from the Ministry of Health, Labor and Welfare (Cardiovascular Diseases), from Pharmaceuticals and Medical Device Agency (Medical Frontier Project) of Japan, and from Protein Research Foundation (Kaneko-Narita Research Grant). The authors are grateful to Drs. H. Kaiya and T.Y. Nakamura of this institute for their helpful discussion, and to Ms. A. Okabe, Y. Takada and S. Fujiwara of this institute for their technical assistance.
PY - 2004/11
Y1 - 2004/11
N2 - In this review, we describe the structure and biological properties of calcitonin receptor-stimulating peptide-1 (CRSP-1), CRSP-2 and CRSP-3, the novel members of the CGRP family. CRSP-1, which has been identified in the pig, cow, dog, and horse, is a specific ligand for the calcitonin (CT) receptor, and porcine CRSP-1 elicits a 100-fold greater effect on a recombinant porcine CT receptor than porcine CT, although this peptide has high structural similarity with CGRP. CRSP-1 is expressed and synthesized mainly in the central nervous system (CNS), pituitary and thyroid gland. In an in vivo experiment, bolus administration of CRSP-1 into rats reduced the plasma calcium concentration, but did not alter blood pressure, indicating its action as a CT receptor agonist in the peripheral circulation. In the CNS, CRSP-1 is also deduced to be an endogenous agonist for the CT receptor. CRSP-2 has been identified in the pig and dog, and CRSP-3 has been identified only in the pig. They are expressed and synthesized mainly in the CNS and thyroid gland. However, their endogenous molecular forms, receptors, and biological activity remain unidentified.
AB - In this review, we describe the structure and biological properties of calcitonin receptor-stimulating peptide-1 (CRSP-1), CRSP-2 and CRSP-3, the novel members of the CGRP family. CRSP-1, which has been identified in the pig, cow, dog, and horse, is a specific ligand for the calcitonin (CT) receptor, and porcine CRSP-1 elicits a 100-fold greater effect on a recombinant porcine CT receptor than porcine CT, although this peptide has high structural similarity with CGRP. CRSP-1 is expressed and synthesized mainly in the central nervous system (CNS), pituitary and thyroid gland. In an in vivo experiment, bolus administration of CRSP-1 into rats reduced the plasma calcium concentration, but did not alter blood pressure, indicating its action as a CT receptor agonist in the peripheral circulation. In the CNS, CRSP-1 is also deduced to be an endogenous agonist for the CT receptor. CRSP-2 has been identified in the pig and dog, and CRSP-3 has been identified only in the pig. They are expressed and synthesized mainly in the CNS and thyroid gland. However, their endogenous molecular forms, receptors, and biological activity remain unidentified.
KW - Calcitonin
KW - Calcitonin gene-related peptide
KW - Calcitonin receptor-stimulating peptide
KW - Central nervous system
KW - cAMP
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U2 - 10.1016/j.peptides.2004.08.013
DO - 10.1016/j.peptides.2004.08.013
M3 - Article
C2 - 15501538
AN - SCOPUS:6344229886
SN - 0196-9781
VL - 25
SP - 2039
EP - 2045
JO - Peptides
JF - Peptides
IS - 11
ER -