Structure-based design of a pathway-specific nuclear import inhibitor

Ahmet E. Cansizoglu, Brittany J. Lee, Zi Chao Zhang, Beatriz M A Fontoura, Yuh Min Chook

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Kapβ2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx(2-5)PY motif. Here we show that Kapβ2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapβ2-specific nuclear import inhibitor, M9M.

Original languageEnglish (US)
Pages (from-to)452-454
Number of pages3
JournalNature Structural and Molecular Biology
Volume14
Issue number5
DOIs
Publication statusPublished - May 2007

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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