Structure-based design of a pathway-specific nuclear import inhibitor

Ahmet E. Cansizoglu, Brittany J. Lee, Zi Chao Zhang, Beatriz M A Fontoura, Yuh Min Chook

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Kapβ2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx(2-5)PY motif. Here we show that Kapβ2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapβ2-specific nuclear import inhibitor, M9M.

Original languageEnglish (US)
Pages (from-to)452-454
Number of pages3
JournalNature Structural and Molecular Biology
Volume14
Issue number5
DOIs
StatePublished - May 2007

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Nuclear Localization Signals
Cell Nucleus Active Transport
Karyopherins
Ligands

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Structure-based design of a pathway-specific nuclear import inhibitor. / Cansizoglu, Ahmet E.; Lee, Brittany J.; Zhang, Zi Chao; Fontoura, Beatriz M A; Chook, Yuh Min.

In: Nature Structural and Molecular Biology, Vol. 14, No. 5, 05.2007, p. 452-454.

Research output: Contribution to journalArticle

Cansizoglu, Ahmet E. ; Lee, Brittany J. ; Zhang, Zi Chao ; Fontoura, Beatriz M A ; Chook, Yuh Min. / Structure-based design of a pathway-specific nuclear import inhibitor. In: Nature Structural and Molecular Biology. 2007 ; Vol. 14, No. 5. pp. 452-454.
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