Structure elucidation of nigricanoside A through enantioselective total synthesis

Jie Chen, Panduka Koswatta, J. Robb DeBergh, Peng Fu, Ende Pan, John B. MacMillan, Joseph M. Ready

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Abstract

Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

Original languageEnglish (US)
Pages (from-to)2932-2937
Number of pages6
JournalChemical Science
Volume6
Issue number5
DOIs
StatePublished - May 1 2015

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ASJC Scopus subject areas

  • Chemistry(all)

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