Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Jose M. Coteron, María Marco, Jorge Esquivias, Xiaoyi Deng, Karen L. White, John White, Maria Koltun, Farah El Mazouni, Sreekanth Kokkonda, Kasiram Katneni, Ravi Bhamidipati, David M. Shackleford, Iñigo Angulo-Barturen, Santiago B. Ferrer, María Belén Jiménez-Díaz, Francisco Javier Gamo, Elizabeth J. Goldsmith, William N. Charman, Ian Bathurst, David FloydDavid Matthews, Jeremy N. Burrows, Pradipsinh K. Rathod, Susan A. Charman, Margaret A. Phillips

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