Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Michael V. Airola, Prajna Shanbhogue, Achraf A. Shamseddine, Kip E. Guja, Can E. Senkal, Rohan Maini, Nana Bartke, Bill X. Wu, Lina M. Obeid, Miguel Garcia-Diaz, Yusuf A. Hannun, David W. Russell

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Medicine & Life Sciences