Structure of maltoheptaose by difference Fourier methods and a model for glycogen

E. Goldsmith, S. Sprang, R. Fletterick

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Abstract

The structure of the glucose heptamer, maltoheptaose, has been determined by difference Fourier analysis at 0.25 nm resolution through its binding to phosphorylase a. It is a left-handed helical structure, with 6.5 glucose residues per turn and a rise per residue of 2.4 Å. The molecule shows short-range order when no protein is present to stabilize its conformation in solution. With one exception, the individual torsion angles between sugar residues vary over a narrow range and preserve a good O(2)O(3′) hydrogen bond. The length of an individual chain for glycogen can be extrapolated from the maltoheptaose data and agrees well with the size for glycogen predicted by the Whelan model.

Original languageEnglish (US)
Pages (from-to)411-427
Number of pages17
JournalJournal of Molecular Biology
Volume156
Issue number2
DOIs
StatePublished - Apr 5 1982

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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