Structure of (-)-neodysidenin from Dysidea herbacea. Implications for biosynthesis of 5,5,5-trichloroleucine peptides

John B. MacMillan, Eugene K. Trousdale, Tadeusz F. Molinski

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

(equation presented) Neodysidenin was isolated from the marine sponge Dysidea herbacea (Keller 1889) collected on the Great Barrier Reef. The complete configuration was obtained from a combination of methods, including capillary electrophoresis of Marfey's derivatives. Neodysidenin belongs to the L-series of trichloroleucine peptides, and the configuration of the N-methyl thiazolyl alanine residue (13R) is opposite to that of dysidenin.

Original languageEnglish (US)
Pages (from-to)2721-2723
Number of pages3
JournalOrganic Letters
Volume2
Issue number17
StatePublished - Aug 24 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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