TY - JOUR
T1 - Structure of poly d(A) o poly d(t)
AU - Chandrasekaran, R.
AU - Radha, A.
N1 - Funding Information:
We thank the National Institutes of Health for financial support (GM 38909).
PY - 1992/8
Y1 - 1992/8
N2 - On the basis of the x-ray data from polycrystalline and well oriented fibers of the sodium salt of poly d(A) o poly d(T) (Arnott et al, Nucl. Acids Res. 11, 4141-4155 (1983)), a revised fi’-DNA model incorporatingiMike adenine and thymine strands is shown to give a much better x-ray agreement (R = 0.25) than the previously assigned model consisting of mixed sugar conformations in the two strands. The narrowing of the minor and the widening of the major grooves are promiscuous features off?’-DNA which are common to all poly d(purine) o poly d(pyrimidine) duplexes with two hydrogen bonded base-pairs and are in marked contrast with classical 5-DNA. Due to modest propeller (-15°), the cross strand diagonal hydrogen bonds (0.37 nm) in this duplex are not as strong as those in AT-rich oligonucleotide crystal structures.
AB - On the basis of the x-ray data from polycrystalline and well oriented fibers of the sodium salt of poly d(A) o poly d(T) (Arnott et al, Nucl. Acids Res. 11, 4141-4155 (1983)), a revised fi’-DNA model incorporatingiMike adenine and thymine strands is shown to give a much better x-ray agreement (R = 0.25) than the previously assigned model consisting of mixed sugar conformations in the two strands. The narrowing of the minor and the widening of the major grooves are promiscuous features off?’-DNA which are common to all poly d(purine) o poly d(pyrimidine) duplexes with two hydrogen bonded base-pairs and are in marked contrast with classical 5-DNA. Due to modest propeller (-15°), the cross strand diagonal hydrogen bonds (0.37 nm) in this duplex are not as strong as those in AT-rich oligonucleotide crystal structures.
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U2 - 10.1080/07391102.1992.10508635
DO - 10.1080/07391102.1992.10508635
M3 - Article
C2 - 1418738
AN - SCOPUS:0026698646
SN - 0739-1102
VL - 10
SP - 153
EP - 168
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 1
ER -