Structure of the beta-form of poly d(A).poly d(U).

R. Chandrasekaran, A. Radha, H. S. Park, S. Arnott

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The crystalline beta-form of the sodium salt of poly d(A).poly d(U) trapped in oriented fibers forms a Watson-Crick base-paired, 10(1) double-helix of pitch 3.2 nm. Two molecules are present in a monoclinic unit cell apparently isomorphous with beta-poly d(A).poly d(T). The two chains in each molecule both carry C2'-endo puckered furanose rings but are conformationally not identical. The orientations of the A:U base-pairs relative to the helix-axis are distinctly different from those in classical B-DNA and the overall morphology of the duplex in which they reside resembles that of the alpha-forms of poly (purine).poly (pyrimidine) DNA duplexes previously reported.

Original languageEnglish (US)
Pages (from-to)1203-1215
Number of pages13
JournalJournal of biomolecular structure & dynamics
Volume6
Issue number6
StatePublished - Jun 1989

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Poly T
B-Form DNA
Poly U
Base Pairing
Salts
Sodium
DNA
pyrimidine
purine

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Chandrasekaran, R., Radha, A., Park, H. S., & Arnott, S. (1989). Structure of the beta-form of poly d(A).poly d(U). Journal of biomolecular structure & dynamics, 6(6), 1203-1215.

Structure of the beta-form of poly d(A).poly d(U). / Chandrasekaran, R.; Radha, A.; Park, H. S.; Arnott, S.

In: Journal of biomolecular structure & dynamics, Vol. 6, No. 6, 06.1989, p. 1203-1215.

Research output: Contribution to journalArticle

Chandrasekaran, R, Radha, A, Park, HS & Arnott, S 1989, 'Structure of the beta-form of poly d(A).poly d(U).', Journal of biomolecular structure & dynamics, vol. 6, no. 6, pp. 1203-1215.
Chandrasekaran, R. ; Radha, A. ; Park, H. S. ; Arnott, S. / Structure of the beta-form of poly d(A).poly d(U). In: Journal of biomolecular structure & dynamics. 1989 ; Vol. 6, No. 6. pp. 1203-1215.
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