Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

Heike Kütt, Joachim Herz, Keith K. Stanley

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalBBA - Gene Structure and Expression
Volume1009
Issue number3
DOIs
StatePublished - Dec 22 1989

Keywords

  • Apolipoprotein E receptor
  • LRP promoter
  • Lipoprotein receptor
  • Low density lipoprotein
  • Promoter

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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