Studies of HLA-B27-associated disease

Joel D Taurog, Jaime P. Durand, Fouad A K El-Zaatari, Robert E Hammer

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Abstract

Several rheumatic diseases were first shown to be associated with human leukocytic antigen (HLA)-B27 in 1973. Recent developments in understanding this association include the finding that there are at least six variants of HLA-B27 at the molecular level, with no one variant preferentially associated with disease. Detailed studies of the structure of the HLA-B27 molecular family are in progress in several laboratories. Mice expressing HLA-B27 and transmitting it to their offspring (transgenic mice) have been produced and are being studied for their response to bacteria that are known to trigger reactive arthritis in B27+ humans. A particular restriction fragment length polymorphism was recently claimed to be a genetic marker for an additional risk factor in ankylosing spondylitis, but two other laboratories have failed to confirm this finding.

Original languageEnglish (US)
Pages (from-to)59-60
Number of pages2
JournalThe American journal of medicine
Volume85
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 23 1988

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ASJC Scopus subject areas

  • Nursing(all)

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