Studies of HLA-B27-associated disease

Joel D Taurog, Jaime P. Durand, Fouad A K El-Zaatari, Robert E Hammer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several rheumatic diseases were first shown to be associated with human leukocytic antigen (HLA)-B27 in 1973. Recent developments in understanding this association include the finding that there are at least six variants of HLA-B27 at the molecular level, with no one variant preferentially associated with disease. Detailed studies of the structure of the HLA-B27 molecular family are in progress in several laboratories. Mice expressing HLA-B27 and transmitting it to their offspring (transgenic mice) have been produced and are being studied for their response to bacteria that are known to trigger reactive arthritis in B27+ humans. A particular restriction fragment length polymorphism was recently claimed to be a genetic marker for an additional risk factor in ankylosing spondylitis, but two other laboratories have failed to confirm this finding.

Original languageEnglish (US)
Pages (from-to)59-60
Number of pages2
JournalThe American journal of medicine
Volume85
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 23 1988

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Antigens
Reactive Arthritis
Ankylosing Spondylitis
Rheumatic Diseases
Genetic Markers
Restriction Fragment Length Polymorphisms
Transgenic Mice
Bacteria

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Studies of HLA-B27-associated disease. / Taurog, Joel D; Durand, Jaime P.; El-Zaatari, Fouad A K; Hammer, Robert E.

In: The American journal of medicine, Vol. 85, No. 6 SUPPL. 1, 23.12.1988, p. 59-60.

Research output: Contribution to journalArticle

Taurog, Joel D ; Durand, Jaime P. ; El-Zaatari, Fouad A K ; Hammer, Robert E. / Studies of HLA-B27-associated disease. In: The American journal of medicine. 1988 ; Vol. 85, No. 6 SUPPL. 1. pp. 59-60.
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