Studies on a transplantable murine rhabdomyosarcoma

K. Perk, A. F. Gazdar, E. R. Russell

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Abstract

Well differentiated rhabdomyosarcomas developed in 8 of 10 BALB/c mice inoculated with cell free extracts of two lesions arising in bats previously inoculated with the Moloney strain of murine sarcoma virus. The tumors could be transplanted into BALB/c mice and other strains of mice compatible at the H 2 locus. A tumorigenic clonal cell culture line (R2) was established from a transplanted tumor. Ultrastructural studies of the primary and transplanted tumors and R2 cells revealed thick and thin myofilaments characteristic of myoblasts. These cells contained numerous cisternal type A virus like particles, but no type C particles were found. Attempts to recover, rescue or chemically induce transforming or nontransforming viruses from transplantable tumors and the R2 cell line were unsuccessful. The tumor cells lacked the murine type C virus gs antigen. Hybridization data confirmed the apparent lack of viral RNA in the tumor cells.

Original languageEnglish (US)
Pages (from-to)1207-1213
Number of pages7
JournalJournal of the National Cancer Institute
Volume54
Issue number5
Publication statusPublished - 1975

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Perk, K., Gazdar, A. F., & Russell, E. R. (1975). Studies on a transplantable murine rhabdomyosarcoma. Journal of the National Cancer Institute, 54(5), 1207-1213.