Studies on cell adhesion. II. Adhesion of cells to surfaces of diverse chemical composition and inhibition of adhesion by sulfhydryl binding reagents

Frederick Grinnell, Mary Milam, Paul A. Srere

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Rat hepatoma cells are able to adhere to many surfaces of diverse chemical compositions. Adhesion to different kinds of surfaces was inhibited when cells were treated with sulfhydryl binding reagents, but not with inhibitors of transport, respiration, and glycolysis. Inhibition of adhesion by p-mercuribenozate and arsenite was reversible; inhibition by HgCl2, iodoacetate and N-ethylmaleimide was not reversible. Cell adhesion is discussed in terms of current theories of chemical adhesion.

Original languageEnglish (US)
Pages (from-to)193-198
Number of pages6
JournalArchives of Biochemistry and Biophysics
Volume153
Issue number1
DOIs
StatePublished - Nov 1972

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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