Studies on mechanisms for enhanced clearance of low‐density lipoproteins in patients with primary hypertriglyceridaemia

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14 Scopus citations

Abstract

Abstract Vega GL, Grundy SM (Center for Human Nutrition and Departments of Clinical Nutrition, Internal Medicine and Biochemistry. University of Texas Southwestern Medical Center at Dallas, and Veterans Administration Medical Center, Dallas, Texas, USA). Studies on mechanisms for enhanced clearance of low‐density lipoproteins in patients with primary hypertriglyceridaemia. Patients with primary hypertriglyceridaemia usually have increased clearance rates for plasma low‐density lipoproteins (LDL). To evaluate the mechanisms for this effect, simultaneous turnover rates for autologous and normal homologous LDL were determined in 12 patients with primary hypertriglyceridaemia. On average, the autologous LDL was cleared more rapidly than the normal homologous LDL. Fractional catabolic rates (FCRs) for autologous LDL averaged 0.61 ± 0.06(SEM) pools d−1, whereas FCRs for homologous LDL averaged 0.49 ± 0.04 pools d−1. In eight of the 12 patients the FCRs for ‘hypertriglyceridaemic’ LDL were found to be significantly higher than for normal LDL; in four others both forms of LDL were cleared at essentially the same rate. In all cases, however, both for the normal and ‘hypertriglyceridaemic’ LDL, clearance rates were higher than normal. Thus, besides the variability in LDL affinity for removal pathways, hypertriglyceridaemic patients appear to have an increased availability of LDL receptors for removal of circulating LDL. 1989 Association for the Publication of the Journal of Internal Medicine

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalJournal of Internal Medicine
Volume226
Issue number1
DOIs
StatePublished - Jul 1989

Keywords

  • LDL kinetics
  • hypertriglyceridaemia
  • low‐density lipoproteins

ASJC Scopus subject areas

  • Internal Medicine

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