Studies on microemulsions using Brij 96 as surfactant and glycerin, ethylene glycol and propylene glycol as cosurfactants

Neelima J. Kale, Loyd V. Allen

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

The existence of microemulsion regions was investigated in quaternary systems composed of Brij 96.cosurfactant/mineral oil/water by constructing phase diagrams. The cosurfactants used were glycerin, ethylene glycol and propylene glycol, all of which are polyhydroxy compounds used widely in the pharmaceutical industry. Light scattering data was used to determine the diameter of the internal phase as a function of the surfactant:cosurfactant ratio at a constant internal phase/oil ratio. Results suggest that the surfactant:cosurfactant ratio is an important parameter in determining the size of the internal phase of these microemulsion systems.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume57
Issue number2
DOIs
StatePublished - Dec 22 1989

Keywords

  • Brij 96
  • Ethylene glycol
  • Glycerin
  • Light scattering
  • Microemulsions
  • Phase diagrams
  • Propylene glycol

ASJC Scopus subject areas

  • Pharmaceutical Science

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