Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate

G. H. Jacobi, R. J. Moore, J. D. Wilson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The conditions under which dihydrotestosterone and 5α-androstane-3α,17β-diol (3α-androstanediol) induce prostatic growth in the castrate dog have been investigated in animals in which the initial size of the prostate was either normal or large. When androgen replacement was commenced immediately after castration of dogs with preexisting prostatic hypertrophy, dihydrotestosterone was as effective as 3α-androstanediol in maintaining prostate weight. Under all other conditions examined (replacement commenced immediately after castration in dogs with small prostates or 2 weeks after castration in dogs with large prostates), 3α-androstanediol but not dihydrotestosterone induced significant prostatic growth. The maximal effect of 3α-androstanediol in inducing prostatic growth was observed in 12 weeks. The administration of 17β-estradiol enhanced the growth-promoting action of 3α-androstanediol, but did not affect the action of dihydrotestosterone or influence 3α-hydroxysteroid dehydrogenase activity in prostate. Thus, the synergistic effect of 17β-estradiol and 3α-androstanediol seems to be independent of any effect on the interconversion of the two androgens. The activity of the 3α-hydroxysteroid dehydrogenase in dog prostate was high under all conditions of accelerated prostatic growth and appeared to be under androgenic control.

Original languageEnglish (US)
Pages (from-to)1748-1755
Number of pages8
JournalEndocrinology
Volume102
Issue number6
StatePublished - 1978

Fingerprint

Prostate
Dihydrotestosterone
Dogs
Castration
Growth
3-Hydroxysteroid Dehydrogenases
Androgens
Androstane-3,17-diol
Estradiol
Prostatic Hyperplasia
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Jacobi, G. H., Moore, R. J., & Wilson, J. D. (1978). Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate. Endocrinology, 102(6), 1748-1755.

Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate. / Jacobi, G. H.; Moore, R. J.; Wilson, J. D.

In: Endocrinology, Vol. 102, No. 6, 1978, p. 1748-1755.

Research output: Contribution to journalArticle

Jacobi, GH, Moore, RJ & Wilson, JD 1978, 'Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate', Endocrinology, vol. 102, no. 6, pp. 1748-1755.
Jacobi, G. H. ; Moore, R. J. ; Wilson, J. D. / Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate. In: Endocrinology. 1978 ; Vol. 102, No. 6. pp. 1748-1755.
@article{e3bfd938bb3644529fb50414a34a7fc8,
title = "Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate",
abstract = "The conditions under which dihydrotestosterone and 5α-androstane-3α,17β-diol (3α-androstanediol) induce prostatic growth in the castrate dog have been investigated in animals in which the initial size of the prostate was either normal or large. When androgen replacement was commenced immediately after castration of dogs with preexisting prostatic hypertrophy, dihydrotestosterone was as effective as 3α-androstanediol in maintaining prostate weight. Under all other conditions examined (replacement commenced immediately after castration in dogs with small prostates or 2 weeks after castration in dogs with large prostates), 3α-androstanediol but not dihydrotestosterone induced significant prostatic growth. The maximal effect of 3α-androstanediol in inducing prostatic growth was observed in 12 weeks. The administration of 17β-estradiol enhanced the growth-promoting action of 3α-androstanediol, but did not affect the action of dihydrotestosterone or influence 3α-hydroxysteroid dehydrogenase activity in prostate. Thus, the synergistic effect of 17β-estradiol and 3α-androstanediol seems to be independent of any effect on the interconversion of the two androgens. The activity of the 3α-hydroxysteroid dehydrogenase in dog prostate was high under all conditions of accelerated prostatic growth and appeared to be under androgenic control.",
author = "Jacobi, {G. H.} and Moore, {R. J.} and Wilson, {J. D.}",
year = "1978",
language = "English (US)",
volume = "102",
pages = "1748--1755",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Studies on the mechanism of 3α-androstanediol-induced growth of the dog prostate

AU - Jacobi, G. H.

AU - Moore, R. J.

AU - Wilson, J. D.

PY - 1978

Y1 - 1978

N2 - The conditions under which dihydrotestosterone and 5α-androstane-3α,17β-diol (3α-androstanediol) induce prostatic growth in the castrate dog have been investigated in animals in which the initial size of the prostate was either normal or large. When androgen replacement was commenced immediately after castration of dogs with preexisting prostatic hypertrophy, dihydrotestosterone was as effective as 3α-androstanediol in maintaining prostate weight. Under all other conditions examined (replacement commenced immediately after castration in dogs with small prostates or 2 weeks after castration in dogs with large prostates), 3α-androstanediol but not dihydrotestosterone induced significant prostatic growth. The maximal effect of 3α-androstanediol in inducing prostatic growth was observed in 12 weeks. The administration of 17β-estradiol enhanced the growth-promoting action of 3α-androstanediol, but did not affect the action of dihydrotestosterone or influence 3α-hydroxysteroid dehydrogenase activity in prostate. Thus, the synergistic effect of 17β-estradiol and 3α-androstanediol seems to be independent of any effect on the interconversion of the two androgens. The activity of the 3α-hydroxysteroid dehydrogenase in dog prostate was high under all conditions of accelerated prostatic growth and appeared to be under androgenic control.

AB - The conditions under which dihydrotestosterone and 5α-androstane-3α,17β-diol (3α-androstanediol) induce prostatic growth in the castrate dog have been investigated in animals in which the initial size of the prostate was either normal or large. When androgen replacement was commenced immediately after castration of dogs with preexisting prostatic hypertrophy, dihydrotestosterone was as effective as 3α-androstanediol in maintaining prostate weight. Under all other conditions examined (replacement commenced immediately after castration in dogs with small prostates or 2 weeks after castration in dogs with large prostates), 3α-androstanediol but not dihydrotestosterone induced significant prostatic growth. The maximal effect of 3α-androstanediol in inducing prostatic growth was observed in 12 weeks. The administration of 17β-estradiol enhanced the growth-promoting action of 3α-androstanediol, but did not affect the action of dihydrotestosterone or influence 3α-hydroxysteroid dehydrogenase activity in prostate. Thus, the synergistic effect of 17β-estradiol and 3α-androstanediol seems to be independent of any effect on the interconversion of the two androgens. The activity of the 3α-hydroxysteroid dehydrogenase in dog prostate was high under all conditions of accelerated prostatic growth and appeared to be under androgenic control.

UR - http://www.scopus.com/inward/record.url?scp=0018141747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018141747&partnerID=8YFLogxK

M3 - Article

VL - 102

SP - 1748

EP - 1755

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -