Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Jonathan M. Graff, R. Scott Thies, Jeffrey J. Song, Anthony J. Celeste, Douglas A. Melton

Research output: Contribution to journalArticle

422 Scopus citations

Abstract

We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.

Original languageEnglish (US)
Pages (from-to)169-179
Number of pages11
JournalCell
Volume79
Issue number1
DOIs
StatePublished - Oct 7 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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