Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.

I. M. Dozmorov; I. I. Kuzin; N. I. Lutsan; G. V. Lutsenko; A. L. Prokhorova; A. M. Sapozhnikov; T. M. Andronova; V. T. Ivanov

Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.

I. M. Dozmorov, I. I. Kuzin, N. I. Lutsan, G. V. Lutsenko, A. L. Prokhorova, A. M. Sapozhnikov, T. M. Andronova, V. T. Ivanov

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Abstract

The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.

Original language	English (US)
Pages (from-to)	651-658
Number of pages	8
Journal	Biomedical science
Volume	2
Issue number	6
State	Published - 1991

Cite this

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title = "Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.",

abstract = "The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.",

author = "Dozmorov, {I. M.} and Kuzin, {I. I.} and Lutsan, {N. I.} and Lutsenko, {G. V.} and Prokhorova, {A. L.} and Sapozhnikov, {A. M.} and Andronova, {T. M.} and Ivanov, {V. T.}",

year = "1991",

language = "English (US)",

volume = "2",

pages = "651--658",

journal = "Biomedical science",

issn = "0955-9701",

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T1 - Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.

AU - Dozmorov, I. M.

AU - Kuzin, I. I.

AU - Lutsan, N. I.

AU - Lutsenko, G. V.

AU - Prokhorova, A. L.

AU - Sapozhnikov, A. M.

AU - Andronova, T. M.

AU - Ivanov, V. T.

PY - 1991

Y1 - 1991

N2 - The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.

AB - The immunomodulatory activities of two synthetic muramylpeptides (MP), a muramyl dipeptide and a glucosaminyl-muramyl dipeptide, have been compared and have been found to exhibit many common features in their effects. In addition, the differential effects of low and high concentrations of MP on the primary humoral immune response in vitro were examined in detail. At high concentrations MP augmented the frequency of induced T-suppressor cells, while at low concentrations the primary immune response was stimulated by enhancement of the antigen-presenting function of accessory cells and by increasing the frequency of induced T-helper cells.

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AN - SCOPUS:0026365857

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JO - Biomedical science

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ER -

Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.

Abstract

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