Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol

James D. Madden; Norman F. Gant; Paul C. MacDonald

doi:10.1016/0002-9378(78)90773-1

Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol

James D. Madden, Norman F. Gant, Paul C. MacDonald

Obstetrics & Gynecology

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19 Scopus citations

Abstract

The transfer constants of conversion of maternal plasma dehydroisoandrosterone sulfate to estradiol ([ρ] DS-E₂ BU) and to 16_αOH-dehydroisoandrosterone sulfate ([ρ] DS-16OHDS BU) and of maternal plasma 16_αOH-dehydroisoandrosterone sulfate to estriol ([ρ] 16OHDS-E₃ BU) were measured in women late in pregnancy. The mean [ρ] 16OHDS-E₃ BU, 0.17, was considerably less than the mean [ρ] DS-E₂ BU, 0.29. However, the extent of 16_α-hydroxylation of maternal plasma dehydroisoandrosterone sulfate was great, the mean [ρ] DS-16OHDS BU being 0.36.

Original language	English (US)
Pages (from-to)	392-395
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	132
Issue number	4
DOIs	https://doi.org/10.1016/0002-9378(78)90773-1
State	Published - Oct 15 1978

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(78)90773-1

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Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol. / Madden, James D.; Gant, Norman F.; MacDonald, Paul C.
In: American journal of obstetrics and gynecology, Vol. 132, No. 4, 15.10.1978, p. 392-395.

Research output: Contribution to journal › Article › peer-review

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title = "Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol",

abstract = "The transfer constants of conversion of maternal plasma dehydroisoandrosterone sulfate to estradiol ([ρ] DS-E2 BU) and to 16αOH-dehydroisoandrosterone sulfate ([ρ] DS-16OHDS BU) and of maternal plasma 16αOH-dehydroisoandrosterone sulfate to estriol ([ρ] 16OHDS-E3 BU) were measured in women late in pregnancy. The mean [ρ] 16OHDS-E3 BU, 0.17, was considerably less than the mean [ρ] DS-E2 BU, 0.29. However, the extent of 16α-hydroxylation of maternal plasma dehydroisoandrosterone sulfate was great, the mean [ρ] DS-16OHDS BU being 0.36.",

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note = "Funding Information: Supported in part by United States Public Health Grants Nos. HD-08360 and AM-06912.",

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AU - MacDonald, Paul C.

N1 - Funding Information: Supported in part by United States Public Health Grants Nos. HD-08360 and AM-06912.

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AB - The transfer constants of conversion of maternal plasma dehydroisoandrosterone sulfate to estradiol ([ρ] DS-E2 BU) and to 16αOH-dehydroisoandrosterone sulfate ([ρ] DS-16OHDS BU) and of maternal plasma 16αOH-dehydroisoandrosterone sulfate to estriol ([ρ] 16OHDS-E3 BU) were measured in women late in pregnancy. The mean [ρ] 16OHDS-E3 BU, 0.17, was considerably less than the mean [ρ] DS-E2 BU, 0.29. However, the extent of 16α-hydroxylation of maternal plasma dehydroisoandrosterone sulfate was great, the mean [ρ] DS-16OHDS BU being 0.36.

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Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol

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