Study of the kinetics of conversion of maternal plasma dehydroisoandrosterone sulfate to 16α-hydroxydehydroisoandrosterone sulfate, estradiol, and estriol

James D. Madden, Norman F. Gant, Paul C. MacDonald

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The transfer constants of conversion of maternal plasma dehydroisoandrosterone sulfate to estradiol ([ρ] DS-E2 BU) and to 16αOH-dehydroisoandrosterone sulfate ([ρ] DS-16OHDS BU) and of maternal plasma 16αOH-dehydroisoandrosterone sulfate to estriol ([ρ] 16OHDS-E3 BU) were measured in women late in pregnancy. The mean [ρ] 16OHDS-E3 BU, 0.17, was considerably less than the mean [ρ] DS-E2 BU, 0.29. However, the extent of 16α-hydroxylation of maternal plasma dehydroisoandrosterone sulfate was great, the mean [ρ] DS-16OHDS BU being 0.36.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume132
Issue number4
DOIs
StatePublished - Oct 15 1978

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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