Study of the metabolic clearance rate of dehydroisoandrosterone sulfate in pregnancy

Norman F. Gant, Harry T. Hutchinson, Pentti K. Siiteri, Paul C. MacDonald

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128 Scopus citations

Abstract

The metabolic clearance rate (MCR) of dehydroisoandrosterone sulfate (DS) was determined in nonpregnant women, normal pregnant women, and pregnant women with pre-eclampsia. The MCR of DS in normal pregnant women was markedly elevated compared with that of nonpregnant subjects, while in those women with severe pre-eclampsia the MCRDS was much lower. A prospective study in teen-age primigravid subjects demonstrated that, in those who remained normal, a progressive increase in the MCRDS continued until delivery. In those young women who ultimately developed pre-eclampsia, the MCRDS initially rose to a degree comparable to that of or greater than that observed in those subjects who remained normal; however, rather than the MCRDS continuing to increase progressively until delivery, in those subjects who ultimately developed pre-eclampsia, the MCRDS began to decrease 3 to 4 weeks prior to the development of clinically evident disease. This observed decline in MCRDS continued thereafter for the remainder of pregnancy.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Volume111
Issue number4
DOIs
StatePublished - Oct 15 1971

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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