TY - JOUR
T1 - Study of the metabolic clearance rate of dehydroisoandrosterone sulfate in pregnancy
AU - Gant, Norman F.
AU - Hutchinson, Harry T.
AU - Siiteri, Pentti K.
AU - MacDonald, Paul C.
N1 - Funding Information:
From the Department of Obstetrics and Gynecology, The University of Texas (Southwestern) Medical School. part by Service This study was supported in United States Public Health Grant HD-00107.
PY - 1971/10/15
Y1 - 1971/10/15
N2 - The metabolic clearance rate (MCR) of dehydroisoandrosterone sulfate (DS) was determined in nonpregnant women, normal pregnant women, and pregnant women with pre-eclampsia. The MCR of DS in normal pregnant women was markedly elevated compared with that of nonpregnant subjects, while in those women with severe pre-eclampsia the MCRDS was much lower. A prospective study in teen-age primigravid subjects demonstrated that, in those who remained normal, a progressive increase in the MCRDS continued until delivery. In those young women who ultimately developed pre-eclampsia, the MCRDS initially rose to a degree comparable to that of or greater than that observed in those subjects who remained normal; however, rather than the MCRDS continuing to increase progressively until delivery, in those subjects who ultimately developed pre-eclampsia, the MCRDS began to decrease 3 to 4 weeks prior to the development of clinically evident disease. This observed decline in MCRDS continued thereafter for the remainder of pregnancy.
AB - The metabolic clearance rate (MCR) of dehydroisoandrosterone sulfate (DS) was determined in nonpregnant women, normal pregnant women, and pregnant women with pre-eclampsia. The MCR of DS in normal pregnant women was markedly elevated compared with that of nonpregnant subjects, while in those women with severe pre-eclampsia the MCRDS was much lower. A prospective study in teen-age primigravid subjects demonstrated that, in those who remained normal, a progressive increase in the MCRDS continued until delivery. In those young women who ultimately developed pre-eclampsia, the MCRDS initially rose to a degree comparable to that of or greater than that observed in those subjects who remained normal; however, rather than the MCRDS continuing to increase progressively until delivery, in those subjects who ultimately developed pre-eclampsia, the MCRDS began to decrease 3 to 4 weeks prior to the development of clinically evident disease. This observed decline in MCRDS continued thereafter for the remainder of pregnancy.
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U2 - 10.1016/0002-9378(71)90472-8
DO - 10.1016/0002-9378(71)90472-8
M3 - Article
C2 - 4255314
AN - SCOPUS:0015227562
SN - 0002-9378
VL - 111
SP - 555
EP - 563
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -