The metabolic clearance rate (MCR) of dehydroisoandrosterone sulfate (DS) was determined in nonpregnant women, normal pregnant women, and pregnant women with pre-eclampsia. The MCR of DS in normal pregnant women was markedly elevated compared with that of nonpregnant subjects, while in those women with severe pre-eclampsia the MCRDS was much lower. A prospective study in teen-age primigravid subjects demonstrated that, in those who remained normal, a progressive increase in the MCRDS continued until delivery. In those young women who ultimately developed pre-eclampsia, the MCRDS initially rose to a degree comparable to that of or greater than that observed in those subjects who remained normal; however, rather than the MCRDS continuing to increase progressively until delivery, in those subjects who ultimately developed pre-eclampsia, the MCRDS began to decrease 3 to 4 weeks prior to the development of clinically evident disease. This observed decline in MCRDS continued thereafter for the remainder of pregnancy.
ASJC Scopus subject areas
- Obstetrics and Gynecology