Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety

Thomas Ritz, Juliet L. Kroll, Sina Aslan, Thomas Janssens, David A. Khan, Amy E. Pinkham, E. Sherwood Brown

Research output: Contribution to journalArticle

Abstract

Asthma as a chronic inflammatory disease can be expected to affect central nervous system structures but little is known about subcortical structures in asthma and their potential association with illness-specific outcomes and anxiety. A total of 40 young adults (20 with asthma and 20 gender- and age-matched controls) underwent high-resolution T1-weighted MRI scan, viewed short distressing film clips, and filled in questionnaires about anxious and depressed mood, as well as asthma history, control, and catastrophizing thoughts about asthma, for those with asthma. The structural scans were processed in FSL’s FIRST program to delineate subcortical structures of interest: amygdala, hippocampus, putamen, pallidum, caudate nucleus, nucleus accumbens, and thalamus. Findings showed no general reduction in subcortical gray matter volumes in asthma compared to controls. Asthma duration, asthma control, and catastrophizing of asthma and asthma attacks were negatively associated with volumes of putamen and pallidum, and to a weaker extent thalamus and amygdala, while controlling for gender, age, and corticosteroid inhaler use. In addition, stronger anxiety in response to distressing films was associated with lower volume of the pallidum, whereas general anxious and depressed mood was unrelated to subcortical structures. Thus, although there are no subcortical structural differences between young adults with asthma and healthy controls, longer asthma history, suboptimal management, and illness-related anxiety are reflected in lower gray matter volumes of subcortical structures, further emphasizing the importance of maintaining optimal asthma control.

Original languageEnglish (US)
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Asthma
Anxiety
Globus Pallidus
Catastrophization
Putamen
Gray Matter
Amygdala
Thalamus
Young Adult
Caudate Nucleus
Nebulizers and Vaporizers
Nucleus Accumbens
Motion Pictures
Surgical Instruments
Hippocampus
Adrenal Cortex Hormones
Chronic Disease
Central Nervous System
Magnetic Resonance Imaging

Keywords

  • Anxiety
  • Asthma
  • Asthma management
  • Basal ganglia
  • Gray matter volume
  • Limbic system
  • Structural magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Subcortical gray matter volumes in asthma : associations with asthma duration, control, and anxiety. / Ritz, Thomas; Kroll, Juliet L.; Aslan, Sina; Janssens, Thomas; Khan, David A.; Pinkham, Amy E.; Brown, E. Sherwood.

In: Brain Imaging and Behavior, 01.01.2019.

Research output: Contribution to journalArticle

@article{42a2806f5b7e4c0997558e323eb0ed7e,
title = "Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety",
abstract = "Asthma as a chronic inflammatory disease can be expected to affect central nervous system structures but little is known about subcortical structures in asthma and their potential association with illness-specific outcomes and anxiety. A total of 40 young adults (20 with asthma and 20 gender- and age-matched controls) underwent high-resolution T1-weighted MRI scan, viewed short distressing film clips, and filled in questionnaires about anxious and depressed mood, as well as asthma history, control, and catastrophizing thoughts about asthma, for those with asthma. The structural scans were processed in FSL’s FIRST program to delineate subcortical structures of interest: amygdala, hippocampus, putamen, pallidum, caudate nucleus, nucleus accumbens, and thalamus. Findings showed no general reduction in subcortical gray matter volumes in asthma compared to controls. Asthma duration, asthma control, and catastrophizing of asthma and asthma attacks were negatively associated with volumes of putamen and pallidum, and to a weaker extent thalamus and amygdala, while controlling for gender, age, and corticosteroid inhaler use. In addition, stronger anxiety in response to distressing films was associated with lower volume of the pallidum, whereas general anxious and depressed mood was unrelated to subcortical structures. Thus, although there are no subcortical structural differences between young adults with asthma and healthy controls, longer asthma history, suboptimal management, and illness-related anxiety are reflected in lower gray matter volumes of subcortical structures, further emphasizing the importance of maintaining optimal asthma control.",
keywords = "Anxiety, Asthma, Asthma management, Basal ganglia, Gray matter volume, Limbic system, Structural magnetic resonance imaging",
author = "Thomas Ritz and Kroll, {Juliet L.} and Sina Aslan and Thomas Janssens and Khan, {David A.} and Pinkham, {Amy E.} and Brown, {E. Sherwood}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11682-019-00188-3",
language = "English (US)",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",

}

TY - JOUR

T1 - Subcortical gray matter volumes in asthma

T2 - associations with asthma duration, control, and anxiety

AU - Ritz, Thomas

AU - Kroll, Juliet L.

AU - Aslan, Sina

AU - Janssens, Thomas

AU - Khan, David A.

AU - Pinkham, Amy E.

AU - Brown, E. Sherwood

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Asthma as a chronic inflammatory disease can be expected to affect central nervous system structures but little is known about subcortical structures in asthma and their potential association with illness-specific outcomes and anxiety. A total of 40 young adults (20 with asthma and 20 gender- and age-matched controls) underwent high-resolution T1-weighted MRI scan, viewed short distressing film clips, and filled in questionnaires about anxious and depressed mood, as well as asthma history, control, and catastrophizing thoughts about asthma, for those with asthma. The structural scans were processed in FSL’s FIRST program to delineate subcortical structures of interest: amygdala, hippocampus, putamen, pallidum, caudate nucleus, nucleus accumbens, and thalamus. Findings showed no general reduction in subcortical gray matter volumes in asthma compared to controls. Asthma duration, asthma control, and catastrophizing of asthma and asthma attacks were negatively associated with volumes of putamen and pallidum, and to a weaker extent thalamus and amygdala, while controlling for gender, age, and corticosteroid inhaler use. In addition, stronger anxiety in response to distressing films was associated with lower volume of the pallidum, whereas general anxious and depressed mood was unrelated to subcortical structures. Thus, although there are no subcortical structural differences between young adults with asthma and healthy controls, longer asthma history, suboptimal management, and illness-related anxiety are reflected in lower gray matter volumes of subcortical structures, further emphasizing the importance of maintaining optimal asthma control.

AB - Asthma as a chronic inflammatory disease can be expected to affect central nervous system structures but little is known about subcortical structures in asthma and their potential association with illness-specific outcomes and anxiety. A total of 40 young adults (20 with asthma and 20 gender- and age-matched controls) underwent high-resolution T1-weighted MRI scan, viewed short distressing film clips, and filled in questionnaires about anxious and depressed mood, as well as asthma history, control, and catastrophizing thoughts about asthma, for those with asthma. The structural scans were processed in FSL’s FIRST program to delineate subcortical structures of interest: amygdala, hippocampus, putamen, pallidum, caudate nucleus, nucleus accumbens, and thalamus. Findings showed no general reduction in subcortical gray matter volumes in asthma compared to controls. Asthma duration, asthma control, and catastrophizing of asthma and asthma attacks were negatively associated with volumes of putamen and pallidum, and to a weaker extent thalamus and amygdala, while controlling for gender, age, and corticosteroid inhaler use. In addition, stronger anxiety in response to distressing films was associated with lower volume of the pallidum, whereas general anxious and depressed mood was unrelated to subcortical structures. Thus, although there are no subcortical structural differences between young adults with asthma and healthy controls, longer asthma history, suboptimal management, and illness-related anxiety are reflected in lower gray matter volumes of subcortical structures, further emphasizing the importance of maintaining optimal asthma control.

KW - Anxiety

KW - Asthma

KW - Asthma management

KW - Basal ganglia

KW - Gray matter volume

KW - Limbic system

KW - Structural magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85073924898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073924898&partnerID=8YFLogxK

U2 - 10.1007/s11682-019-00188-3

DO - 10.1007/s11682-019-00188-3

M3 - Article

C2 - 31501976

AN - SCOPUS:85073924898

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

ER -