Substance use disorder comorbidity in major depressive disorder: A confirmatory analysis of the STAR*D cohort

Lori Davis, Elizabeth Frazier, Mustafa Husain, Diane Warden, Madhukar Trivedi, Maurizio Fava, Paolo Cassano, Patrick McGrath, G. K. Balasubramani, Stephen Wisniewski, A. John Rush

Research output: Contribution to journalArticle

64 Scopus citations


The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment (p = 0.048 to < 0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively).

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalAmerican Journal on Addictions
Issue number4
Publication statusPublished - Aug 1 2006


ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this