TY - JOUR
T1 - Substance use disorder comorbidity in major depressive disorder
T2 - A confirmatory analysis of the STAR*D cohort
AU - Davis, Lori
AU - Frazier, Elizabeth
AU - Husain, Mustafa
AU - Warden, Diane
AU - Trivedi, Madhukar
AU - Fava, Maurizio
AU - Cassano, Paolo
AU - McGrath, Patrick
AU - Balasubramani, G. K.
AU - Wisniewski, Stephen
AU - Rush, A. John
PY - 2006/8/1
Y1 - 2006/8/1
N2 - The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment (p = 0.048 to < 0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively).
AB - The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment (p = 0.048 to < 0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively).
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U2 - 10.1080/10550490600754317
DO - 10.1080/10550490600754317
M3 - Article
C2 - 16867922
AN - SCOPUS:33746821038
SN - 1055-0496
VL - 15
SP - 278
EP - 285
JO - American Journal on Addictions
JF - American Journal on Addictions
IS - 4
ER -