Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features

Puneet K. Gupta, Nasreen Sayed, Kan Ding, Mark A. Agostini, Paul C. Van Ness, Stuart Yablon, Christopher Madden, Bruce Mickey, Raimondo D'Ambrosio, Ramon Diaz-Arrastia

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Post-traumatic epilepsy (PTE) is a consequence of traumatic brain injury (TBI), occurring in 10-25% of patients with moderate to severe injuries. The development of animal models for testing antiepileptogenic therapies and validation of biomarkers to follow epileptogenesis in humans necessitates sophisticated understanding of the subtypes of PTE, which is the objective of this study. In this study, retrospective review was performed of patients with moderate to severe TBI with subsequent development of medically refractory epilepsy referred for video-electroencephalography (EEG) monitoring at a single center over a 10-year period. Information regarding details of injury, neuroimaging studies, seizures, video-EEG, and surgery outcomes were collected and analyzed. There were 123 patients with PTE identified, representing 4.3% of all patients evaluated in the epilepsy monitoring unit. Most of them had localization-related epilepsy, of which 57% had temporal lobe epilepsy (TLE), 35% had frontal lobe epilepsy (FLE), and 3% each had parietal and occipital lobe epilepsy. Of patients with TLE, 44% had mesial temporal sclerosis (MTS), 26% had temporal neocortical lesions, and 30% were nonlesional. There was no difference in age at injury between the different PTE subtypes. Twenty-two patients, 13 of whom had MTS, proceeded to surgical resection. At a mean follow-up of 2.5 years, Engel Class I outcomes were seen in 69% of those with TLE and 33% of those with FLE. Our findings suggest PTE is a heterogeneous condition, and careful evaluation with video-EEG monitoring and high resolution MRI can identify distinct syndromes. These results have implications for the design of clinical trials of antiepileptogenic therapies for PTE.

Original languageEnglish (US)
Pages (from-to)1439-1443
Number of pages5
JournalJournal of Neurotrauma
Volume31
Issue number16
DOIs
StatePublished - Aug 15 2014

Fingerprint

Post-Traumatic Epilepsy
Temporal Lobe Epilepsy
Frontal Lobe Epilepsy
Electroencephalography
Partial Epilepsy
Sclerosis
Epilepsy
Wounds and Injuries
Parietal Lobe
Neuroimaging
Seizures
Animal Models
Biomarkers
Clinical Trials
Therapeutics

Keywords

  • EEG
  • post-traumatic epilepsy
  • seizure
  • surgical resection
  • traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Subtypes of post-traumatic epilepsy : clinical, electrophysiological, and imaging features. / Gupta, Puneet K.; Sayed, Nasreen; Ding, Kan; Agostini, Mark A.; Van Ness, Paul C.; Yablon, Stuart; Madden, Christopher; Mickey, Bruce; D'Ambrosio, Raimondo; Diaz-Arrastia, Ramon.

In: Journal of Neurotrauma, Vol. 31, No. 16, 15.08.2014, p. 1439-1443.

Research output: Contribution to journalArticle

Gupta, Puneet K. ; Sayed, Nasreen ; Ding, Kan ; Agostini, Mark A. ; Van Ness, Paul C. ; Yablon, Stuart ; Madden, Christopher ; Mickey, Bruce ; D'Ambrosio, Raimondo ; Diaz-Arrastia, Ramon. / Subtypes of post-traumatic epilepsy : clinical, electrophysiological, and imaging features. In: Journal of Neurotrauma. 2014 ; Vol. 31, No. 16. pp. 1439-1443.
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