Subversion of cell signaling by pathogens

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.

Original languageEnglish (US)
JournalCold Spring Harbor perspectives in biology
Volume4
Issue number9
DOIs
StatePublished - Sep 2012

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Cell signaling
Cell Shape
Pathogens
GTP-Binding Proteins
Innate Immunity
Cell Survival
Viruses
Bacteria
Infection
Machinery
Cells
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Subversion of cell signaling by pathogens. / Alto, Neal M.; Orth, Kim.

In: Cold Spring Harbor perspectives in biology, Vol. 4, No. 9, 09.2012.

Research output: Contribution to journalArticle

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