TY - JOUR
T1 - Subversion of cell signaling by pathogens
AU - Alto, Neal M.
AU - Orth, Kim
PY - 2012/9
Y1 - 2012/9
N2 - Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.
AB - Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.
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U2 - 10.1101/cshperspect.a006114
DO - 10.1101/cshperspect.a006114
M3 - Article
C2 - 22952390
AN - SCOPUS:84866082963
SN - 1943-0264
VL - 4
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 9
ER -