Subversion of cell signaling by pathogens

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Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Biology
Issue number9
StatePublished - Sep 1 2012


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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