Successful management of refractory neonatal seizures with midazolam

Deepa Sirsi, Srishti Nangia, Jacqueline LaMothe, Barry E. Kosofsky, Gail E. Solomon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Seizures are indicative of underlying neurologic dysfunction in neonates. Repeated seizures may be deleterious to the brain even without disturbances of ventilation or perfusion. First-line antiepileptic drugs such as phenobarbital and phenytoin are not very effective in controlling seizures in neonates. Rapid control of status epilepticus with midazolam has been demonstrated in 2 previous studies with complete clinical and electrographic response in neonates who did not respond to phenobarbital and phenytoin. We report our experience with 3 neonates with status epilepticus. Seizures in all 3 neonates did not respond to phenobarbital and phenytoin but responded to midazolam infusion. Midazolam may be considered a safe and effective antiepileptic drug in refractory neonatal seizures of diverse etiologies.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalJournal of Child Neurology
Volume23
Issue number6
DOIs
StatePublished - Jun 2008

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Midazolam
Seizures
Phenytoin
Phenobarbital
Status Epilepticus
Anticonvulsants
Neurologic Manifestations
Ventilation
Perfusion
Brain

Keywords

  • Midazolam
  • Neonatal seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Successful management of refractory neonatal seizures with midazolam. / Sirsi, Deepa; Nangia, Srishti; LaMothe, Jacqueline; Kosofsky, Barry E.; Solomon, Gail E.

In: Journal of Child Neurology, Vol. 23, No. 6, 06.2008, p. 706-709.

Research output: Contribution to journalArticle

Sirsi, Deepa ; Nangia, Srishti ; LaMothe, Jacqueline ; Kosofsky, Barry E. ; Solomon, Gail E. / Successful management of refractory neonatal seizures with midazolam. In: Journal of Child Neurology. 2008 ; Vol. 23, No. 6. pp. 706-709.
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