Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide

Tarek Y. El Ahmadieh, Jack M. Raisanen, James Botros, Jean Luc Kabangu, Edward Pan, Wayne Gluf

Research output: Contribution to journalArticle


Background: Paraspinal masses are a relatively uncommon but diverse group of lesions that can be neoplastic or non-neoplastic. Peripheral primitive neuroectodermal tumors of the lumbar paraspinal region with diffuse and strong glial differentiation have never been reported before. Case Description: We report a primary paraspinal primitive neuroectodermal tumor with overwhelming glial differentiation in a 23-year-old female patient who presented with intractable right lower extremity pain. The patient underwent a 2-staged operation with gross total resection of the mass followed by intensity-modulated radiation therapy and oral temozolomide, a regimen employed for high-grade intracranial gliomas. Serial imaging revealed no evidence of recurrence after 3 years. Conclusions: Although these lesions appear to be exceptionally rare, an approach similar to that of intracranial high-grade glial tumors was effective in our experience. Our patient had no evidence of recurrence at 3-year follow-up.

Original languageEnglish (US)
Pages (from-to)340-344
Number of pages5
JournalWorld Neurosurgery
StatePublished - Nov 1 2018



  • Chemotherapy
  • High glial differentiation
  • Paraspinal mass
  • Paraspinal neoplasm
  • Paraspinal primitive neuroectodermal tumor
  • Radiation
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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