Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome

Y. Sawara, M. Itabashi, C. Kojima, H. Tabata, D. Kamei, K. Kawanishi, T. Moriyama, H. Sugiura, M. Tsukada, T. Takei, T. Ogawa, T. Yoshida, J. Arai, K. Uchida, K. Tsuchiya, K. Nitta

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Minimal change nephrotic syndrome (MCNS) usually is considered to have a good renal prognosis, but the frequency of relapses is a therapeutic challenge to physicians. The treatment of patients with multiple relapses remains a matter of controversy, because few controlled studies are available. We report the case of a 25-year-old man who experienced relapses of MCNS. Single-dose rituximab therapy (total dose 500 mg) was given during the fourth relapse. Complete remission occurred 10 days later, when no CD19/20-positive B cells were detected in the blood. This the first report of efficacy of single-dose rituximab therapy to treat multi-relapsing MCNS in an adult patient.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalClinical Nephrology
Volume72
Issue number1
StatePublished - Oct 26 2009

Keywords

  • Minimal change nephritic syndrome
  • Relapse
  • Remission
  • Rituximab

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome'. Together they form a unique fingerprint.

  • Cite this

    Sawara, Y., Itabashi, M., Kojima, C., Tabata, H., Kamei, D., Kawanishi, K., Moriyama, T., Sugiura, H., Tsukada, M., Takei, T., Ogawa, T., Yoshida, T., Arai, J., Uchida, K., Tsuchiya, K., & Nitta, K. (2009). Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome. Clinical Nephrology, 72(1), 69-72.