Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant

Andrew L. Gilman, Amy Serrano, John Skelley, David Zwick

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report the clinical course of a patient who developed a Rhizopus infection of his right lung and pleural cavity, 11 months after receiving a T-cell-depleted, haploidentical donor peripheral blood stem cell transplant. Thoracotomy was performed to remove the pulmonary lesion, but residual disease in the pleural cavity was noted. Treatment with amphotericin B was complicated by the development of severe renal dysfunction, necessitating alternative antifungal therapy. Treatment was initiated with the investigational triazole posaconazole. Despite concurrent treatment with corticosteroids for graft-versus-host disease (GVHD), the patient had a complete response and remains well 4 years later.

Original languageEnglish (US)
Pages (from-to)959-963
Number of pages5
JournalPediatric Blood and Cancer
Volume47
Issue number7
DOIs
StatePublished - Dec 1 2006

Fingerprint

Zygomycosis
Pleural Cavity
Stem Cells
Tissue Donors
Transplants
Lung
Rhizopus
Triazoles
Amphotericin B
Graft vs Host Disease
Thoracotomy
Complementary Therapies
Adrenal Cortex Hormones
Therapeutics
T-Lymphocytes
Kidney
Infection
posaconazole

Keywords

  • Fungal infection
  • Hematologic malignancy
  • Posaconazole
  • Stem cell transplantation
  • Zygomycosis

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant. / Gilman, Andrew L.; Serrano, Amy; Skelley, John; Zwick, David.

In: Pediatric Blood and Cancer, Vol. 47, No. 7, 01.12.2006, p. 959-963.

Research output: Contribution to journalArticle

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