Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant

Andrew L. Gilman, Amy Serrano, John Skelley, David Zwick

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We report the clinical course of a patient who developed a Rhizopus infection of his right lung and pleural cavity, 11 months after receiving a T-cell-depleted, haploidentical donor peripheral blood stem cell transplant. Thoracotomy was performed to remove the pulmonary lesion, but residual disease in the pleural cavity was noted. Treatment with amphotericin B was complicated by the development of severe renal dysfunction, necessitating alternative antifungal therapy. Treatment was initiated with the investigational triazole posaconazole. Despite concurrent treatment with corticosteroids for graft-versus-host disease (GVHD), the patient had a complete response and remains well 4 years later.

Original languageEnglish (US)
Pages (from-to)959-963
Number of pages5
JournalPediatric Blood and Cancer
Volume47
Issue number7
DOIs
StatePublished - Dec 1 2006

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Keywords

  • Fungal infection
  • Hematologic malignancy
  • Posaconazole
  • Stem cell transplantation
  • Zygomycosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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