Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide

Robert H. Collins, Charles S. White, C. Allen Stringer, Joseph W. Fay

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A patient with gestational trophoblastic neoplasm failed treatment with several standard chemotherapy regimens and had progressive disease with development of lung and brain metastases and a rising HCG level. Following resection of the metastases and whole-brain radiotherapy she was treated with high-dose etoposide and cyclophosphamide. She promptly attained a complete remission and remains free of disease 15 months after completion of therapy. This regimen, although initially developed for leukemia and lymphoma treatment, has potential as a therapy for refractory gestational trophoblastic neoplasm because it delivers high doses of agents very active in this disease.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalGynecologic oncology
Volume43
Issue number3
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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