Abstract
The fifth international conference on SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases, held in Houston, included topics covering the latest advances and new targets in the field of protein modification. This conference report highlights selected presentations on the structural characterization of ubiquitination and SUMOylation machinery; the regulation of ubiquitination enzymes, including E3 ligases; the functions and mechanism of action of SUMO-targeted ubiquitin ligases (STUbLs); the regulation of gene expression by SUMO; non-degradative functions of ubiquitin and SUMO in signal transduction; mechanisms and functions of ISG15 conjugation; the interaction of pathogens with host cell SUMOylation machinery; and stabilization of the Axin protein. Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 224-227 |
| Number of pages | 4 |
| Journal | IDrugs |
| Volume | 13 |
| Issue number | 4 |
| State | Published - Apr 2010 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
Cite this
SUMO, Ubiquitin, UBL proteins : Implications for human diseases-fifth international conference. / Skaug, Brian; Chen, Zhijian J.
In: IDrugs, Vol. 13, No. 4, 04.2010, p. 224-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SUMO, Ubiquitin, UBL proteins
T2 - Implications for human diseases-fifth international conference
AU - Skaug, Brian
AU - Chen, Zhijian J.
PY - 2010/4
Y1 - 2010/4
N2 - The fifth international conference on SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases, held in Houston, included topics covering the latest advances and new targets in the field of protein modification. This conference report highlights selected presentations on the structural characterization of ubiquitination and SUMOylation machinery; the regulation of ubiquitination enzymes, including E3 ligases; the functions and mechanism of action of SUMO-targeted ubiquitin ligases (STUbLs); the regulation of gene expression by SUMO; non-degradative functions of ubiquitin and SUMO in signal transduction; mechanisms and functions of ISG15 conjugation; the interaction of pathogens with host cell SUMOylation machinery; and stabilization of the Axin protein. Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc).
AB - The fifth international conference on SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases, held in Houston, included topics covering the latest advances and new targets in the field of protein modification. This conference report highlights selected presentations on the structural characterization of ubiquitination and SUMOylation machinery; the regulation of ubiquitination enzymes, including E3 ligases; the functions and mechanism of action of SUMO-targeted ubiquitin ligases (STUbLs); the regulation of gene expression by SUMO; non-degradative functions of ubiquitin and SUMO in signal transduction; mechanisms and functions of ISG15 conjugation; the interaction of pathogens with host cell SUMOylation machinery; and stabilization of the Axin protein. Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc).
UR - http://www.scopus.com/inward/record.url?scp=77950195990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950195990&partnerID=8YFLogxK
M3 - Article
VL - 13
SP - 224
EP - 227
JO - IDrugs : the investigational drugs journal
JF - IDrugs : the investigational drugs journal
SN - 1369-7056
IS - 4
ER -