18F fluorocholine dynamic timeof-flight PeT/Mr imaging in patients with newly diagnosed intermediate-to high-risk prostate cancer: Initial clinicalpathologic comparisons

Joon Young Choi, Jaewon Yang, Susan M. Noworolski, Spencer Behr, Albert J. Chang, Jeffry P. Simko, Hao G. Nguyen, Peter R. Carroll, John Kurhanewicz, Youngho Seo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: To investigate the initial clinical value of fluorine 18 (18F) fluorocholine (FCH) dynamic positron emission tomography (PET)/magnetic resonance (MR) imaging by comparing its parameters with clinical-pathologic fndings in patients with newly diagnosed intermediate-to high-risk prostate cancer (PCa) who plan to undergo radical prostatectomy. Materials and Methods: The institutional review board approved the study protocol, and informed written consent was obtained from all subjects for this HIPAA-compliant study. Twelve men (mean age 6 standard deviation, 61.7 years ± 8.4; range, 46-74 years) with untreated intermediate-to high-risk PCa characterized according to Cancer of the Prostate Risk Assessment (CAPRA) underwent preoperative FCH dynamic PET/MR imaging followed by radical prostatectomy between April and November 2015. PET/MR imaging parameters including average and maximum K1 (delivery rate constant) and standardized uptake values (SUVs) and Prostate Imaging Reporting and Data System (PI-RADS) version 2 scores were measured and compared with clinicalpathologic characteristics. For statistical analysis, the Spearman rank correlation and Mann-Whitney U tests were performed. Results: Of the PET parameters, maximum SUV of primary tumors showed signifcant correlations with several clinical-pathologic parameters including serum prostate-specifc antigen level (r = 0.71, P =.01), pathologic stage (r = 0.59, P =.043), and postsurgical CAPRA score (r = 0.72, P =.008). The overall PI-RADS score showed signifcant correlations with pathologic tumor volume (r = 0.81, P <.001), percentage of tumor cells with Gleason scores greater than 3 (r = 0.59, P =.02), and postsurgical CAPRA score (r = 0.58, P =.046). The high-risk postsurgical CAPRA score patient group had a signifcantly higher maximum SUV than did the intermediate-risk group. Combined PET and MR imaging showed improved sensitivity (88%) for prediction of pathologic extraprostatic extension compared with that with MR imaging (50%) and PET (75%) performed separately. Conclusion: Maximum SUVs and PI-RADS scores from FCH PET/MR imaging show good correlation with clinical-pathologic characteristics, such as postsurgical CAPRA score, which are related to prognosis in patients with newly diagnosed intermediate-to high-risk PCa.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalRADIOLOGY
Volume282
Issue number2
DOIs
StatePublished - Mar 2017
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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