1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia

Bo Young Choe, Ki Tae Kim, Tae Suk Suh, Chul Lee, In Ho Paik, Young Whee Bahk, Kyung Sub Shinn, Robert E. Lenkinski

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Rationale and Objectives. We in vestigated the proton metabolism of right prefrontal white matter in drug-naive, chronic schizophrenic patients (n=23), compared with healthy normal control subjects (n=10), by using localized, water-suppressed in vivo 1H magnetic resonance (MR) spectroscopy. Methods.: All 1H MR spectroscopy examinations were performed on a 1.5-T MR imaging/MR spectroscopy system by using a point-resolved spectroscopy pulse sequence for localizd volumes of 2×2×2 cm3. Proton metabolite ratios relative to creatine (Cr) were obtained using a Marquart algorithm. Results.: Drun-naive, chronic schizophrenic patients demonstrated a decrease in the N-acetylaspartate (NAA):Cr and choline (Cho):Cr ratios and an increase of the complex of γ-aminobutyric acid (GABA) and glutamate (Glu) containing ratio [(GABA+Glu):Cr] as compared with normal control subjects. Conclusion.: Results suggest that the reduction of NAA and Cho may indicate neuronal dysfunction and that the elevation of GABA and Glu may play a role in chronic schizophrenia. 1H MR spectroscopy may be a useful modality in research and in the clinical evaluation of chronic schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalAcademic radiology
Volume1
Issue number3
DOIs
StatePublished - Nov 1994

Keywords

  • Magnetic resonance spectroscopy
  • schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Choe, B. Y., Kim, K. T., Suh, T. S., Lee, C., Paik, I. H., Bahk, Y. W., Shinn, K. S., & Lenkinski, R. E. (1994). 1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia. Academic radiology, 1(3), 211-216. https://doi.org/10.1016/S1076-6332(05)80716-0