1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia

Bo Young Choe, Ki Tae Kim, Tae Suk Suh, Chul Lee, In Ho Paik, Young Whee Bahk, Kyung Sub Shinn, Robert E. Lenkinski

Research output: Contribution to journalArticle

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Abstract

Rationale and Objectives. We in vestigated the proton metabolism of right prefrontal white matter in drug-naive, chronic schizophrenic patients (n=23), compared with healthy normal control subjects (n=10), by using localized, water-suppressed in vivo 1H magnetic resonance (MR) spectroscopy. Methods.: All 1H MR spectroscopy examinations were performed on a 1.5-T MR imaging/MR spectroscopy system by using a point-resolved spectroscopy pulse sequence for localizd volumes of 2×2×2 cm3. Proton metabolite ratios relative to creatine (Cr) were obtained using a Marquart algorithm. Results.: Drun-naive, chronic schizophrenic patients demonstrated a decrease in the N-acetylaspartate (NAA):Cr and choline (Cho):Cr ratios and an increase of the complex of γ-aminobutyric acid (GABA) and glutamate (Glu) containing ratio [(GABA+Glu):Cr] as compared with normal control subjects. Conclusion.: Results suggest that the reduction of NAA and Cho may indicate neuronal dysfunction and that the elevation of GABA and Glu may play a role in chronic schizophrenia. 1H MR spectroscopy may be a useful modality in research and in the clinical evaluation of chronic schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalAcademic Radiology
Volume1
Issue number3
DOIs
StatePublished - 1994

Fingerprint

Creatine
Schizophrenia
Magnetic Resonance Spectroscopy
gamma-Aminobutyric Acid
Glutamic Acid
Choline
Pharmaceutical Preparations
Protons
Aminobutyrates
Spectrum Analysis
Magnetic Resonance Imaging
Water
Research
N-acetylaspartate

Keywords

  • Magnetic resonance spectroscopy
  • schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Choe, B. Y., Kim, K. T., Suh, T. S., Lee, C., Paik, I. H., Bahk, Y. W., ... Lenkinski, R. E. (1994). 1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia. Academic Radiology, 1(3), 211-216. https://doi.org/10.1016/S1076-6332(05)80716-0

1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia. / Choe, Bo Young; Kim, Ki Tae; Suh, Tae Suk; Lee, Chul; Paik, In Ho; Bahk, Young Whee; Shinn, Kyung Sub; Lenkinski, Robert E.

In: Academic Radiology, Vol. 1, No. 3, 1994, p. 211-216.

Research output: Contribution to journalArticle

Choe, BY, Kim, KT, Suh, TS, Lee, C, Paik, IH, Bahk, YW, Shinn, KS & Lenkinski, RE 1994, '1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia', Academic Radiology, vol. 1, no. 3, pp. 211-216. https://doi.org/10.1016/S1076-6332(05)80716-0
Choe, Bo Young ; Kim, Ki Tae ; Suh, Tae Suk ; Lee, Chul ; Paik, In Ho ; Bahk, Young Whee ; Shinn, Kyung Sub ; Lenkinski, Robert E. / 1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-neive, chronic schizophrenia. In: Academic Radiology. 1994 ; Vol. 1, No. 3. pp. 211-216.
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