Superior Prognostic Importance of Perineural Invasion vs. Lymph Node Involvement After Curative Resection of Duodenal Adenocarcinoma

Stefano Cecchini, Camilo Correa-Gallego, Vikram Desphande, Matteo Ligorio, Abdulmetin Dursun, Jennifer Wargo, Carlos Fernàndez del Castillo, Andrew Louis Warshaw, Cristina Rosa Ferrone

Research output: Contribution to journalArticle

Abstract

Background: Unlike other gastrointestinal tumors, lymph node involvement has not consistently been a negative prognostic factor for survival in patients with duodenal adenocarcinoma. Our aim is to examine prognostic factors in patients who underwent a curative resection of their duodenal adenocarcinoma. Methods: A retrospective review of 169 patients diagnosed with primary duodenal lesions between 1982 and 2010 was performed, of whom 103 were treated with curative intent. Clinico-pathologic factors were evaluated. Results: A potentially curative resection was performed in 103 patients with a median age of 67 years (range, 22-91). Perineural and lympho-vascular invasion were identified in 30 (29. 1%) and 39 patients (37. 9%), respectively. Median follow-up was 26. 5 months. The 5-year overall survival was 62% vs. 25% for patients with or without nodal metastases (p < 0. 001) and 56% vs. 19% for patients with or without perineural invasion (p < 0. 001), respectively. Lymph node ratio, type of resection, and size of tumor failed to stratify prognosis. By multivariate analysis, perineural invasion was the most powerful independent predictor of survival (HR, 2. 520; CI, 1. 361-4. 664). Conclusions: Perineural invasion is a stronger predictor for recurrence and survival than tumor size, depth of infiltration, lymph node involvement, and type of resection in patients with duodenal adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)113-120
Number of pages8
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Duodenal adenocarcinoma
  • Duodenal cancer
  • Lymph node
  • Nodal metastases
  • Perineural invasion
  • Predictor
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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    Cecchini, S., Correa-Gallego, C., Desphande, V., Ligorio, M., Dursun, A., Wargo, J., Castillo, C. F. D., Warshaw, A. L., & Ferrone, C. R. (2012). Superior Prognostic Importance of Perineural Invasion vs. Lymph Node Involvement After Curative Resection of Duodenal Adenocarcinoma. Journal of Gastrointestinal Surgery, 16(1), 113-120. https://doi.org/10.1007/s11605-011-1704-6