Superoxide dismutase improves organ preservation in liver transplantation

L. M. Olson, G. B. Klintmalm, B. S. Husberg, J. R. Nery, C. W. Whitten, A. W. Paulsen, R. McClure

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

There are several recent reports that demonstrate a beneficial effect of allopurinol in ischemia-induced hepatocellular injury. The purpose of this study was to evaluate the role of the superoxide anion in the mechanism of harvesting injury, using its scavenger enzyme, superoxide dismutase (SOD), in an animal liver transplantation model. There is reasonably good evidence that harvesting injury in liver transplantation occurs as a consequence of a free radical-mediated ischemia reperfusion mechanism. Although the human liver can be successfully preserved under hypothermic conditions four up to ten hours, prolonged hepatic preservation continues to be a major problem. These data support the hypothesis that oxygen radical scavengers are efficacious in improving liver preservation for transplantation.

Original languageEnglish (US)
Pages (from-to)961-964
Number of pages4
JournalTransplantation proceedings
Volume20
Issue number1 SUPPL. 1
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Olson, L. M., Klintmalm, G. B., Husberg, B. S., Nery, J. R., Whitten, C. W., Paulsen, A. W., & McClure, R. (1988). Superoxide dismutase improves organ preservation in liver transplantation. Transplantation proceedings, 20(1 SUPPL. 1), 961-964.