Suppression by Kampo medicines in preneoplastic mammary hyperplastic alveolar nodules of SHN virgin mice

S. Sakamoto, N. Muroi, M. Matsuda, M. Tajima, H. Kudo, N. Kasahara, S. Suzuki, Y. Sugiura, K. Kuwa, H. Namiki, T. Mori, S. Kawashima, H. Nagasawa

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Abstract

Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and Shakuyaku-kanzo-to (SKT) are Japanese modified traditional Chinese herbal medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants, respectively. It is known that the hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in the mammary glands of mice. We examined the effects of SST, KBG, and SKT on the formation and growth of HAN in a high-mammary-tumor strain of SHN virgin mice. Oral administration of SST for 60 days beginning at 90 days of age reduced the number and area of HAN and mammary thymidylate synthetase activity with a reduction of serum prolactin level. There was little difference between the other experimental groups and the control in the formation and growth of HAN and the enzyme activities. These results indicate that SST may have a preventive effect on malignant mammary transformations.

Original languageEnglish (US)
Pages (from-to)425-427
Number of pages3
JournalPlanta Medica
Volume59
Issue number5
DOIs
Publication statusPublished - 1993

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Keywords

  • hyperplastic alveolar nodule (HAN)
  • Kampo medicine
  • mice
  • Sho-saiko-to
  • thymidylate synthetase

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Sakamoto, S., Muroi, N., Matsuda, M., Tajima, M., Kudo, H., Kasahara, N., ... Nagasawa, H. (1993). Suppression by Kampo medicines in preneoplastic mammary hyperplastic alveolar nodules of SHN virgin mice. Planta Medica, 59(5), 425-427. https://doi.org/10.1055/s-2006-959724