Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice

S. Sakamoto; M. Mizuno; H. Kudo; S. Suzuki; N. Kasahara; Y. Sugiura; T. Mori; H. Nagasawa

doi:10.1097/00001813-199312000-00007

Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice

S. Sakamoto, M. Mizuno, H. Kudo, S. Suzuki, N. Kasahara, Y. Sugiura, T. Mori, H. Nagasawa

Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.

Original language	English (US)
Pages (from-to)	651-655
Number of pages	5
Journal	Anti-Cancer Drugs
Volume	4
Issue number	6
DOIs	https://doi.org/10.1097/00001813-199312000-00007
State	Published - 1993

Keywords

5-fluorouracil
DNA synthesizing enzyme
SHN virgin mouse
mouse mammary tumor

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)
Cancer Research

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10.1097/00001813-199312000-00007

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abstract = "Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.",

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author = "S. Sakamoto and M. Mizuno and H. Kudo and S. Suzuki and N. Kasahara and Y. Sugiura and T. Mori and H. Nagasawa",

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AU - Sakamoto, S.

AU - Mizuno, M.

AU - Kudo, H.

AU - Suzuki, S.

AU - Kasahara, N.

AU - Sugiura, Y.

AU - Mori, T.

AU - Nagasawa, H.

PY - 1993

Y1 - 1993

N2 - Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.

AB - Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.

KW - 5-fluorouracil

KW - DNA synthesizing enzyme

KW - SHN virgin mouse

KW - mouse mammary tumor

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Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice

Abstract

Keywords

ASJC Scopus subject areas

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