Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice

S. Sakamoto, M. Mizuno, H. Kudo, S. Suzuki, N. Kasahara, Y. Sugiura, T. Mori, H. Nagasawa

Research output: Contribution to journalArticle

Abstract

Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed not only de novo but also salvage pathways for pyrimidine nucleotide synthesis, and reduced mammary tumorigenesis and tumor growth in SHN virgin mice, which have a high potential for the incidence of mammary tumors.

Original languageEnglish (US)
Pages (from-to)651-655
Number of pages5
JournalAnti-Cancer Drugs
Volume4
Issue number6
StatePublished - 1993

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Tegafur
Uracil
Oral Administration
Pyrimidine Nucleotides
Breast Neoplasms
Carcinogenesis
Incidence
Growth

Keywords

  • 5-fluorouracil
  • DNA synthesizing enzyme
  • mouse mammary tumor
  • SHN virgin mouse

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

Cite this

Sakamoto, S., Mizuno, M., Kudo, H., Suzuki, S., Kasahara, N., Sugiura, Y., ... Nagasawa, H. (1993). Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice. Anti-Cancer Drugs, 4(6), 651-655.

Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice. / Sakamoto, S.; Mizuno, M.; Kudo, H.; Suzuki, S.; Kasahara, N.; Sugiura, Y.; Mori, T.; Nagasawa, H.

In: Anti-Cancer Drugs, Vol. 4, No. 6, 1993, p. 651-655.

Research output: Contribution to journalArticle

Sakamoto, S, Mizuno, M, Kudo, H, Suzuki, S, Kasahara, N, Sugiura, Y, Mori, T & Nagasawa, H 1993, 'Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice', Anti-Cancer Drugs, vol. 4, no. 6, pp. 651-655.
Sakamoto, S. ; Mizuno, M. ; Kudo, H. ; Suzuki, S. ; Kasahara, N. ; Sugiura, Y. ; Mori, T. ; Nagasawa, H. / Suppression of mammary tumors by oral administration of 1-(2- tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice. In: Anti-Cancer Drugs. 1993 ; Vol. 4, No. 6. pp. 651-655.
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