Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

Diego H. Castrillon, Lili Miao, Ramya Kollipara, James W. Horner, Ronald A. DePinho

Research output: Contribution to journalArticlepeer-review

653 Scopus citations

Abstract

Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stages of follicular growth as a suppressor of follicular activation. In addition to providing a molecular entry point for studying the regulation of follicular growth, these results raise the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalScience
Volume301
Issue number5630
DOIs
StatePublished - Jul 11 2003

ASJC Scopus subject areas

  • General

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