Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth

Tae Hyong Kim, Jieun Song, Sheila R. Alcantara Llaguno, Eric Murnan, Sandya Liyanarachchi, Kamalakannan Palanichamy, Ji Yeun Yi, Mariano Sebastian Viapiano, Ichiro Nakano, Sung Ok Yoon, Hong Wu, Luis F. Parada, Chang Hyuk Kwon

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Glioblastoma multiforme (GBM), the most common and aggressive primary brain malignancy, is incurable despite the best combination of current cancer therapies. For the development of more effective therapies, discovery of novel candidate tumor drivers is urgently needed. Here, we report that peroxiredoxin 4 (PRDX4) is a putative tumor driver. PRDX4 levels were highly increased in a majority of human GBMs as well as in a mouse model of GBM. Reducing PRDX4 expression significantly decreased GBM cell growth and radiation resistance in vitro with increased levels of ROS, DNA damage, and apoptosis. In a syngenic orthotopic transplantation model, Prdx4 knockdown limited GBM infiltration and significantly prolonged mouse survival. These data suggest that PRDX4 can be a novel target for GBM therapies in the future.

Original languageEnglish (US)
Article numbere42818
JournalPloS one
Volume7
Issue number8
DOIs
StatePublished - Aug 15 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Kim, T. H., Song, J., Alcantara Llaguno, S. R., Murnan, E., Liyanarachchi, S., Palanichamy, K., Yi, J. Y., Viapiano, M. S., Nakano, I., Yoon, S. O., Wu, H., Parada, L. F., & Kwon, C. H. (2012). Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. PloS one, 7(8), [e42818]. https://doi.org/10.1371/journal.pone.0042818